Dexamethasone distribution characteristic following controllable continuous sub-tenon drug delivery in rabbit

Sub-Tenon Atracurium Injection in Rabbit Eyes;a Histopathologic Study

PURPOSE To evaluate early and late histopathologic changes following posterior sub-Tenon injection of atracurium in the rabbit eye. METHODS This study was performed on 39 healthy white New Zealand rabbits which received sub-Tenon injection of 0.05-0.08 mg/kg atracurium diluted in 0.5 ml normal saline (N/S) in the left and 0.5 ml N/S in the right eyes. Bilateral enuclation was performed one ho...

[Impact of hyaluronidase on anesthetic distribution in retrobulbar region following sub-Tenon anesthesia].

BACKGROUND/AIM Sub-Tenon's block is nowadays commonly used in ophthalmic surgery because of its safety and efficacy. The aim of this study was to investigate the distribution of the anaesthetic solution with different amounts of hyaluronidase in the retrobulbar space, following an injection into the Sub-Tenon's space. METHODS In this experimental study, 40 pig cadaver heads were used (80 eyeb...

in vivo evaluation of novel nanoparticles containing dexamethasone for ocular drug delivery on rabbit eye

In vivo evaluation of novel nanoparticles containing dexamethasone for ocular drug delivery on rabbit eye.

PURPOSE The purpose of this study was to investigate the in vivo effects of a new smart polymer loaded with dexamethasone on inflamed rabbit eye. MATERIALS AND METHODS Polymeric micelles were prepared using N-isopropylacrylamide (NIPAAM), vinyl pyrrolidone (VP), and methacrylate (MAA) as monomers in the presence of N,N-methylene bis-acrylamide (MBA) and triethyleneglycol dimethacrylate (TEGDM...

Myocardial drug distribution pattern following intrapericardial delivery: an MRI analysis.

OBJECTIVES The main goal was to gain insights into the pharmacokinetics of intrapericardial drug delivery using magnetic resonance (MR) imaging analysis and the extracellular MR contrast agent gadopentetate dimeglumine (Gd-DTPA) as a model. BACKGROUND Recent development of catheter-based techniques to access the intact pericardial space has increased interest in intrapericardial delivery for ...